Hoechst 33258 是一種熒光染料，用于 DNA 染色。
K-115產(chǎn)品描述：K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. IC50 value: 31 nM [1] Target: ROCK inhibitor K-115 had selective and potent inhibitory effects on ROCKs. In rabbits, topical instillation of K-115 significantly reduced IOP in a dose-dependent manner. Maximum IOP reduction was observed 1 h after topical instillation, which was 8.55±1.09 mmHg (mean±SE) from the baseline IOP at 0.5%. In monkeys, maximum IOP reduction was observed 2 h after topical instillation, which was 4.36±0.32 mmHg from the baseline IOP at 0.4%, and was significantly stronger than that of 0.005% latanoprost. Whole-head autoradiography showed that the radioactivity level was maximum at 15 min after instillation of [(14)C]K-115 in the ipsilateral eye [3]. NC-induced oxidative stress, including oxidation of lipids and production of ROS, was significantly attenuated by K-1


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產(chǎn)品鏈接：www.medchemexpress.cn/K-115.html


Purity:98%
MWt:424.4977
Formula:C25H24N6O
SMILES:OC1=CC=C(C2=NC3=CC=C(C4=NC5=CC=C(N6CCN(C)CC6)C=C5N4)C=C3N2)C=C1
Pathway:Others;
Mechanisms:Others;
Research Area:Cancer
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