TZ9是泛素結(jié)合酶（E2 enzyme）Rad6新型抑制劑，抑制MDA-MB-231細(xì)胞增殖的IC50值約為6uM。
AMG 837 (sodium salt)產(chǎn)品描述：AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. AMG 837 is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. showed no significant activity in cell-based assays against PPARα, δ, and γ. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50 = 3 uM) on the a2-adrenergic receptor. Overall, AMG 837 was both highly pote


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產(chǎn)品鏈接：www.medchemexpress.cn/AMG-837-sodium-salt.html


Purity:98%
MWt:366.3309
Formula:C17H14N6O4
SMILES:O=C(OCC1=NC(N)=NC(NC2=CC=CC=C2)=N1)C3=CC=C([N+]([O-])=O)C=C3
Pathway:metabolic Enzyme/Protease;
Mechanisms:E1/E2/E3 Enzyme;
Research Area:Cancer
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