<
| 產(chǎn)品名稱：<a href="http://www.medchemexpress.cn/TAK-438-free-base.html">TAK-438 free base</a>__TAK-438 (free base)是一種新型的鉀競爭性的酸阻斷劑，可逆抑制H+/K+,ATPase，IC50為19 nM (pH 6.5)。<BR>產(chǎn)品化學(xué)信息：Molecular Weight<br> 345.39<br> Formula<br>C??H??FN?O?S<br>CAS No.<br>881681-00-1<br>Storage<br> Powder -20°C<br> 3 years 4°C<br> 2 years In solvent -80°C<br> 6 months -20°C<br> 1 month Shipping<br>Room temperature in continental US; may vary elsewher<br>Solvent & Solubility<br>DMSO: ≥ 33 mg/mL<br><br>* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.<br> [1]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/22512618">Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.</a><br> [2]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/20624992">Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.</a><br> [3]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/21411494">Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.</a><br><BR>實(shí)驗(yàn)方法參考：References<br/> [1]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22512618" rel="nofollow" target="_blank">Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.</a><br> [2]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20624992" rel="nofollow" target="_blank">Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.</a><br> [3]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21411494" rel="nofollow" target="_blank">Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.</a><br><BR>產(chǎn)品研究領(lǐng)域：<a href="http://www.medchemexpress.cn/Pathways/Membrane Transporter_Ion Channel.html"><span>Membrane Transporter/Ion Channel</span></a><a href="http://www.medchemexpress.cn/Targets/Proton Pump.html"><span>Proton Pump</span></a><BR>TAK-438 free base相關(guān)產(chǎn)品<a href="http://www.medchemexpress.cn/TAK-438.html" target="_blank">TAK-438</a> | <a href="http://www.medchemexpress.cn/Omeprazole.html" target="_blank">Omeprazole</a> | <a href="http://www.medchemexpress.cn/Pantoprazole-sodium.html" target="_blank">Pantoprazole sodium</a> | <a href="http://www.medchemexpress.cn/_R_-Lansoprazole.html" target="_blank">(R)-Lansoprazole</a> | <a href="http://www.medchemexpress.cn/zinc-pyrithione.html" target="_blank">Zinc Pyrithione</a> | <a href="http://www.medchemexpress.cn/AZD0865.html" target="_blank">AZD0865</a> | <a href="http://www.medchemexpress.cn/Ilaprazole.html" target="_blank">Ilaprazole</a> | <a href="http://www.medchemexpress.cn/esomeprazole-magnesium-trihydrate.html" target="_blank">Esomeprazole Magnesium trihydrate</a> | <a href="http://www.medchemexpress.cn/Bamaquimast.html" target="_blank">Bamaquimast</a> | <a href="http://www.medchemexpress.cn/Rabeprazole-sodium.html" target="_blank">Rabeprazole sodium</a> | <a href="http://www.medchemexpress.cn/Soraprazan.html" target="_blank">Soraprazan</a> | <a href="http://www.medchemexpress.cn/Chebulinic-acid.html" target="_blank">Chebulinic acid</a> | <a href="http://www.medchemexpress.cn/Picoprazole.html" target="_blank">Picoprazole</a> | <a href="http://www.medchemexpress.cn/SKF96067.html" target="_blank">SKF96067</a> | <a href="http://www.medchemexpress.cn/Tenatoprazole_sodium.html" target="_blank">Tenatoprazole sodium</a> | 公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI8K、MAPK等近千個細(xì)分靶點(diǎn),中文<a href=""http://www.medchemexpress.cn"">http://www.medchemexpress.cn</a><br>英文：<a href=""http://www.medchemexpress.com"">http://www.medchemexpress.com</a> |
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