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1-NM-PP1研究進(jìn)展

發(fā)布日期:2017-11-02   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/1-NM-PP1.html1-NM-PP1/a產(chǎn)品描述:1-NM-PP1 inhibits bCdk7/b recovered from the muta
1-NM-PP1產(chǎn)品描述:1-NM-PP1 inhibits Cdk7 recovered from the mutant, but not the wild-type cells with an IC50 of ~50 nM with either substrate.IC50 & Target: CDK7[1]In Vitro: Cdk7 from Cdk7as/as or Cdk7+/+ cells is immunoprecipitated and tested its kinase activity towards both a Pol II CTD-containing fusion protein (GST-CTD) and human Cdk2. Cdk7 recovered from the mutant, but not the wild-type, cells is inhibited by 1-NM-PP1 (1-NMPP1), with an IC50 of ~50 nM with either substrate. Replacement of wild-type Cdk7 with Cdk7as/as also rendered growth of HCT116 cells sensitive to 1-NM-PP1. In the absence of 1-NM-PP1, the wild-type andCdk7as/as cells had population doubling times of ~17.9 and ~20.2 h, respectively, with similar cell-cycle distributions in asynchronous culture, indicating minimal impairment of Cdk7 function by the F91G mutation per se. The homozygous Cdk7as/a


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