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Laquinimod研究進(jìn)展

發(fā)布日期:2017-11-01   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/Laquinimod.htmlLaquinimod/a產(chǎn)品描述:Laquinimod is a potent immunomodulator.ibIn V
Laquinimod產(chǎn)品描述:Laquinimod is a potent immunomodulator.In Vitro: Laquinimod reverses EAE and inhibits pathogenic T cell immune responses. Laquinimod reverses RR-EAE and inhibits inflammatory T cell responses via a direct effect on myeloid APC. Laquinimod alters myeloid APC subsets and inhibits Th1 and Th17 polarization of myelin-specific T cells. Laquinimod-induced type II (M2) monocytes reverse established EAE[1]. Laquinimod modulates the phenotype of B cells of healthy donors. Laquinimod modulates expression of markers related to regulatory capacity in B cells of RRMS patients. Laquinimod reduces IFNγ cytokine expression in CD4+ T cells[2]. In Vivo: Laquinimod treatment inhibits donor myelin-specific T cells from transferring EAE to naive recipient mice. In vivo laquinimod treatment alters subpopulations of myeloid antigen presenting cells (APC) that include a decrease in CD11c+CD11b+CD4+ dendritic cel


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