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2614W94研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/2614W94.html2614W94/a產(chǎn)品描述：2614W94 is a selective, reversible inhibitor of bmo
<a href="https://www.medchemexpress.com/2614W94.html">2614W94</a>產(chǎn)品描述：2614W94 is a selective, reversible inhibitor of <b>monoamine oxidase-A</b> with a competitive mechanism of inhibition and <b>IC<sub>50</sub></b> of 5 nM and <b>K<sub>i</sub></b> of 1.6 nM with serotonin as substrate.

IC50 & Target: IC50: 5 nM (Monoamine Oxidase)<sup>[1]</sup><br/>

Ki: 1.6 nM (Monoamine Oxidase)<sup>[1]</sup>

<i><b>In Vitro:</b></i> 2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM<sup>[1]</sup>.

<i><b>In Vivo:</b></i> 2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED<sub>50</sub> of 1.1 mg/kg<sup>[1]</sup>. <br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/2614W94.html">www.medchemexpress.cn/2614W94.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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