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HTS01037研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/HTS01037.htmlHTS01037/a產(chǎn)品描述：HTS01037 is an inhibitor of bfatty acid/b binding
<a href="https://www.medchemexpress.com/HTS01037.html">HTS01037</a>產(chǎn)品描述：HTS01037 is an inhibitor of <b>fatty acid</b> binding; and a competitive antagonist of <b>protein-protein</b> interactions mediated by AFABP/aP2 with a <b>K<sub>i</sub></b> of 0.67 μM.

IC50 & Target: IC50: 0.67 μM (AFABP/aP2)<sup>[1]</sup>

<i><b>In Vitro:</b></i> HTS01037 functions as a high affinity ligand of AFABP/aP2 with an apparent K<sub>i</sub> of 0.67 μM. HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells<sup>[1]</sup>. Treatment of microglial cells with HTS01037 increases expression of Ucp2 and arginase in the presence or absence of palmitic acid. Moreover, cells exposed to HTS01037 exhibits attenuated expression of inducible nitric oxide s<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/hts01037.html">www.medchemexpress.cn/hts01037.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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