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Methyl-β-cyclodextrin研究進(jìn)展

發(fā)布日期:2017-10-30   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/Methyl-_beta_-cyclodextrin.htmlMethyl--cyclodextrin/a產(chǎn)品描述:Methyl--cyclodextri
<a href="https://www.medchemexpress.com/Methyl-_beta_-cyclodextrin.html">Methyl-β-cyclodextrin</a>產(chǎn)品描述:Methyl-β-cyclodextrin, a cyclic heptasaccharide, is an effective agent for the depletion of cholesterol from cells; also inhibits PEL cell growth with an <b>IC<sub>50</sub></b> of 3.33-4.23 mM.

IC50 & Target: IC50: 3.33-4.23 mM (PEL cell growth)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs<sup>[2]</sup>. Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol dep<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接:<a href="http://www.medchemexpress.cn/methyl-_beta_-cyclodextrin.html">www.medchemexpress.cn/methyl-_beta_-cyclodextrin.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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