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ISCK03研究進展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/ISCK03.htmlISCK03/a產(chǎn)品描述：ISCK03 is a specific bSCF/c-Kit/b inhibitor.ibIn Vitr
<a href="https://www.medchemexpress.com/ISCK03.html">ISCK03</a>產(chǎn)品描述：ISCK03 is a specific <b>SCF/c-Kit</b> inhibitor.

<i><b>In Vitro:</b></i> Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins<sup>[1]</sup>. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions<sup>[2]</sup>.

<i><b>In Vivo:</b></i> Oral administration of ISCK03 induces the dose-dependent dep<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/isck03.html">www.medchemexpress.cn/isck03.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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