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PGD2-IN-1研究進展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/PGD2-IN-1.htmlPGD2-IN-1/a產(chǎn)品描述：PGD2-IN-1 is an antagonist of bDP/b extracted f
<a href="https://www.medchemexpress.com/PGD2-IN-1.html">PGD2-IN-1</a>產(chǎn)品描述：PGD2-IN-1 is an antagonist of <b>DP</b> extracted from patent WO 2006044732 A2, example 15 (d); has an <b>IC<sub>50</sub></b> of 0.3 nM.

IC50 & Target: IC50: 0.3 nM<sup>[1]</sup>

<i><b>In Vitro:</b></i> Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion<sup>[2]</sup>.



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