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NIH-12848研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/NIH-12848.htmlNIH-12848/a產(chǎn)品描述：NIH-12848 is a putative phosphatidylinositol 5-
<a href="https://www.medchemexpress.com/NIH-12848.html">NIH-12848</a>產(chǎn)品描述：NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (<b>PI5P4Kγ</b>) inhibitor with an <b>IC<sub>50</sub></b> of 1 μM.

IC50 & Target: IC50: 1 μM (PI5P4Kγ)<sup>[1]</sup>

<i><b>In Vitro:</b></i> NIH-12848 inhibits PI5P4Kγ with an IC<sub>50</sub> of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na<sup>+</sup>/ K<sup>+</sup>-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks<sup>[1]</sup>.

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src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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