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Iberin研究進展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Iberin.htmlIberin/a產(chǎn)品描述：Iberin, a sulfoxide analogue of sulforaphane, is a na
<a href="https://www.medchemexpress.com/Iberin.html">Iberin</a>產(chǎn)品描述：Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an <b>IC<sub>50</sub></b> of 2.3 μM in HL60 cell.

IC50 & Target: IC50: 2.3 μM (HL60 cell)<sup>[1]</sup>

<i><b>In Vitro:</b></i>  Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP<sup>[2]</sup>. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9<sup>[3]</sup>.

<i><b>In Vivo:</b></i> Iberin is tested in an <i>in vivo</i> foreign-body infe<br><br>
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已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/iberin.html">www.medchemexpress.cn/iberin.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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