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Cyclo(his-pro)研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Cyclo_his-pro_.htmlCyclo(his-pro)/a產(chǎn)品描述：Cyclo(His-Pro) is a cyclic dipeptide
<a href="https://www.medchemexpress.com/Cyclo_his-pro_.html">Cyclo(his-pro)</a>產(chǎn)品描述：Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone.

<i><b>In Vitro:</b></i> Cyclo(His-Pro) is a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone. Cyclo(His-Pro) is ubiquitous in the central nervous system and is a key substrate of organic cation transporters, which are strongly linked to neuroprotection. The cyclic dipeptide can also cross the brain-blood-barrier and, once in the brain, can affect diverse inflammatory and stress responses by modifying the Nrf2-NF-κB signaling axis<sup>[1]</sup>. Cyclo(His-Pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway<sup>[2]</sup>.

<i><b>In Vivo:</b></i> Mice that receives cyclo(His-Pro) pre-treatment shows a significant decrease in the oedematogenic response, confirming that the cyclic dipeptide can exert anti-inflammato<br><br>
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