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3-(Methylthio)propionic acid研究

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/3-_Methylthio_propionic_acid.html3-(Methylthio)propionic acid/a產(chǎn)品描述：3-(Methyl
<a href="https://www.medchemexpress.com/3-_Methylthio_propionic_acid.html">3-(Methylthio)propionic acid</a>產(chǎn)品描述：3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.

<i><b>In Vitro:</b></i> Methionine has consistently been shown to be the most toxic amino acid in experiments devised to assess the relative toxicity of dietary amino acids. 3-methylthiopropionate is an intermediate in methionine catabolism in rat and monkey liver <i>in vitro</i>. This pathway appears to account for a major portion of methionine oxidation <i>in vitro</i><sup>[1]</sup>. Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid<sup>[2]</sup>. The purified 3-MTPA has antifungal activity in assays using <i>F. oxysporum</i> as a model fungus. Daily measurements of shoot and root length shows severe inhibition of seed germination and root and shoot development at concentrati<br><br>
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