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Allopurinol riboside研究進(jìn)展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Allopurinol_riboside.htmlAllopurinol riboside/a產(chǎn)品描述：Allopurinol riboside, a m
<a href="https://www.medchemexpress.com/Allopurinol_riboside.html">Allopurinol riboside</a>產(chǎn)品描述：Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

<i><b>In Vitro:</b></i> Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a K<sub>i</sub> of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside<sup>[1]</sup>. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/allopurinol-riboside.html">www.medchemexpress.cn/allopurinol-riboside.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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