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WAY-200070研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/WAY-200070.htmlWAY-200070/a產(chǎn)品描述：WAY-200070 is a selective estrogen receptor(b
<a href="https://www.medchemexpress.com/WAY-200070.html">WAY-200070</a>產(chǎn)品描述：WAY-200070 is a selective estrogen receptor β (<b>ERRβ</b>) agonist with an <b>IC<sub>50</sub></b> of 2.3 nM.

IC50 & Target: IC50: 2.3 nM (ERRβ), 155 nM (ERRα)<sup>[1]</sup>

<i><b>In Vivo:</b></i> Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect<sup>[1]</sup>. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected<sup>[2]</sup>. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator<sup>[3]</sup>. WAY-200070, shows significantly decr<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/way-200070.html">www.medchemexpress.cn/way-200070.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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