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Kinetin riboside研究進展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Kinetin_riboside.htmlKinetin riboside/a產(chǎn)品描述：Kinetin riboside, a cytokinin ana
<a href="https://www.medchemexpress.com/Kinetin_riboside.html">Kinetin riboside</a>產(chǎn)品描述：Kinetin riboside, a cytokinin analog, can induce <b>apoptosis</b> in cancer cells. It inhibits the proliferation of HCT-15 cells with an <b>IC<sub>50</sub></b> of 2.5 μM.

IC50 & Target: IC50: 2.5 μM (HCT-15 cells)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC<sub>50</sub>=2.5 μM)<sup>[1]</sup>. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure<sup>[2]</sup>.



<i><b>In Vivo:</b></i> Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg<sup>[2]</sup>.<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/kinetin-riboside.html">www.medchemexpress.cn/kinetin-riboside.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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