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CXCR2-IN-1研究進展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/CXCR2-IN-1.htmlCXCR2-IN-1/a產(chǎn)品描述：CXCR2-IN-1 is a central nervous system penetr
<a href="https://www.medchemexpress.com/CXCR2-IN-1.html">CXCR2-IN-1</a>產(chǎn)品描述：CXCR2-IN-1 is a central nervous system penetrant <b>CXCR2</b> antagonists with a <b>pIC<sub>50</sub></b> of 9.3.

IC50 & Target: pIC50: 9.3 (CXCR2)<sup>[1]</sup>

<i><b>In Vitro:</b></i> CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)<sup>[1]</sup>.



<i><b>In Vivo:</b></i> CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis<sup>[1]</sup>.<br><br>
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