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MX69研究進展

發(fā)布日期:2017-10-27   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/MX69.htmlMX69/a產品描述:MX69 is an inhibitor of bMDM2/XIAP/b, used for cancer tre
<a href="https://www.medchemexpress.com/MX69.html">MX69</a>產品描述:MX69 is an inhibitor of <b>MDM2/XIAP</b>, used for cancer treatment.

<i><b>In Vitro:</b></i> MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro<sup>[1]</sup>.

<i><b>In Vivo:</b></i> MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo<sup>[1]</sup>.<br><br>
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已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產品鏈接:<a href="http://www.medchemexpress.cn/mx69.html">www.medchemexpress.cn/mx69.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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