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UNC3866研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/UNC3866.htmlUNC3866/a產(chǎn)品描述：UNC3866 is a potent antagonist of the bCBX7/b-H3 in
<a href="https://www.medchemexpress.com/UNC3866.html">UNC3866</a>產(chǎn)品描述：UNC3866 is a potent antagonist of the <b>CBX7</b>-H3 interaction as determined by AlphaScreen (<b>IC<sub>50</sub></b>=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.

IC50 & Target: IC50: 66±1.2 nM (CBX7)<sup>[1]</sup>

<i><b>In Vitro:</b></i> UNC3866, a potent antagonist of the methyl-lysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently with a K<sub>d</sub> of 100 nM for each, and is 6- to 18-fold selective versus seven other CBX and CDY chromodomains while being highly selective versus >250 other protein targets. UNC3866 inhibits PC3 cell proliferation, a known CBX7 phenotype, while UNC4219, a methylated negative control compound, has negligible effects. UNC3866 is a potent and cellularly active antagonist of PRC1 chromodomains. UNC3866 is the most potent ligand reported for CBX7 with a K<sub>d</sub> of 97±2.4 nM<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/unc3866.html">www.medchemexpress.cn/unc3866.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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