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NCB-0846研究進展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/NCB-0846.htmlNCB-0846/a產(chǎn)品描述：NCB-0846 is an orally available bTNIK/b inhibitor
<a href="https://www.medchemexpress.com/NCB-0846.html">NCB-0846</a>產(chǎn)品描述：NCB-0846 is an orally available <b>TNIK</b> inhibitor with an <b>IC<sub>50</sub></b> of 21 nM.

IC50 & Target: IC50: 21 nM (NCB-0846)<sup>[1]</sup>

<i><b>In Vitro:</b></i> NCB-0846 has anti-Wnt activity. NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 shows inhibitory activity against TNIK with an IC<sub>50</sub> of 21 nM. NCB-0846 also inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK. NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK within a concentration range of 0.1-0.3 μM and completely inhibits the phosphorylation of TCF4 at a concentration of 3 μM. NCB-0846 inhibits HCT116 cell growth and shows much higher (-20-fold) inhibitory activity against colony formation by the same cells in soft agar<sup>[1]</sup>.

<i><b>In Vivo:</b></i> NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MY<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/ncb-0846.html">www.medchemexpress.cn/ncb-0846.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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