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Hypotaurine研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Hypotaurine.htmlHypotaurine/a產(chǎn)品描述：Hypotaurine (2-aminoethanesulfinic acid), a
<a href="https://www.medchemexpress.com/Hypotaurine.html">Hypotaurine</a>產(chǎn)品描述：Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the <b>glycine receptor</b>.

<i><b>In Vitro:</b></i> Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan<sup>[1]</sup>. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion<sup>[2]</sup>.

<i><b>In Vivo:</b></i> Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical a<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/hypotaurine.html">www.medchemexpress.cn/hypotaurine.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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