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4E2RCat

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/4E2RCat.html4E2RCat/a產(chǎn)品描述：4E2RCat is an inhibitor of beIF4E-eIF4G/b interacti
<a href="https://www.medchemexpress.com/4E2RCat.html">4E2RCat</a>產(chǎn)品描述：4E2RCat is an inhibitor of <b>eIF4E-eIF4G</b> interaction with an <b>IC<sub>50</sub></b> of 13.5 μM.

IC50 & Target: IC50: 13.5 μM (eIF4E-eIF4G)<sup>[1]</sup>

<i><b>In Vitro:</b></i> 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner<sup>[1]</sup>.

<i><b>In Vivo:</b></i> 4E2RCat inhibits protein synthesis <i>in vivo</i> and it is not a consequence of increased cell death<sup>[1]</sup>.<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/4e2rcat.html">www.medchemexpress.cn/4e2rcat.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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