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BMT-145027

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/BMT-145027.htmlBMT-145027/a產(chǎn)品描述：BMT-145027 is an bmGluR5/b positive allosteri
<a href="https://www.medchemexpress.com/BMT-145027.html">BMT-145027</a>產(chǎn)品描述：BMT-145027 is an <b>mGluR5</b> positive allosteric modulator without inherent agonist activity, exhibits an <b>EC<sub>50</sub></b> of 47 nM.

IC50 & Target: IC50: 47 nM (mGluR5)<sup>[1]</sup>

<i><b>In Vitro:</b></i> BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC<sub>50</sub>=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM<sup>[1]</sup>.

<i><b>In Vivo:</b></i> Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object prefer<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/bmt-145027.html">www.medchemexpress.cn/bmt-145027.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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