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Stibogluconate (sodium)

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Stibogluconate-sodium.htmlStibogluconate (sodium)/a產(chǎn)品描述：Stibogluconate sodium
<a href="https://www.medchemexpress.com/Stibogluconate-sodium.html">Stibogluconate (sodium)</a>產(chǎn)品描述：Stibogluconate sodium is  is a potent inhibitor of PTPases Src homology PTPase1 (SHP-1), SHP-2, and PTP1B, inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10 μg/ml, 100 μg/ml respectively.

target: SHP-1, SHP-2, PTP1B.[1]

In vitro: Stibogluconate sodium inhibits protein tyrosine phosphatases. Stibogluconate sodium targets the SHP-1 PTPase catalytic domain and forms stable complexes with the phosphatase. Stibogluconate sodium induces tyrosine phosphorylation of cellular proteins and augments IL-3-induces Jak2/Stat5 phosphorylation in Baf3 cells. Stibogluconate sodium augments IL-3-induced cell proliferation of Baf3 cells. [1]

In vivo: SSG induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumorinfiltrating macrophages (M). [2]

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