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Necrosulfonamide

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Necrosulfonamide.htmlNecrosulfonamide/a產(chǎn)品描述：Necrosulfonamide is a pharmacolog
<a href="https://www.medchemexpress.com/Necrosulfonamide.html">Necrosulfonamide</a>產(chǎn)品描述：Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29.

target: MLKL[1]

IC50 : 124 nM.

In vitro: Necrosulfonamide significantly decreases BV6/DAC-induced cell death in MV4-11 cells.[1] Treating cells with necrosulfonamide or knocking down MLKL expression arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells.  necrosulfonamide had no effect on apoptosis induced by TNF-α plus Smac mimetic in non-RIP3-expressing Panc-1 cells.[2]  Complete inhibition was observed at NSA concentration of 0.5  M. NSA is also an effective inhibitor of the necroptotic pathway induced by STS in the presence of caspase inhibitor. [3]

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