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Ro 67-7476

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Ro-67-7476.htmlRo 67-7476/a產(chǎn)品描述：Ro 67-7476 is a positive allosteric modulator
<a href="https://www.medchemexpress.com/Ro-67-7476.html">Ro 67-7476</a>產(chǎn)品描述：Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.  Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.

target: mGlu1

EC 50: 60.1 nM

(1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control).

(2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM.

(3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.

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