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CA-074 methyl ester

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/CA-074-methyl-ester.htmlCA-074 methyl ester/a產(chǎn)品描述：CA-074 methyl ester is a sp
<a href="https://www.medchemexpress.com/CA-074-methyl-ester.html">CA-074 methyl ester</a>產(chǎn)品描述：CA-074 methyl ester is a specific inhibitor of <b>Cathepsin B</b>, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.

<i><b>In Vitro:</b></i> CA-074Me (5 μM and 50 μM) inhibits RANKL-induced osteoclastogenesis in BMM cells derived from C57BL/6J and NOD/ShiLtJ mice. CA-074Me exerts its anti-osteoclastogenic effect within 24 hours post-RANKL stimulation in vitro. CA-074Me does not exert its anti-osteoclastogenic effect via the MAPK-ERK signaling cascade. CA-074Me inhibits c-FOS upregulation and subsequent NFATc1 autoamplification following RANKL stimulation.<sup>[2]</sup>. CA-074Me reduces apoptosis induced by CVB1<sup>[3]</sup>.

<i><b>In Vivo:</b></i> Hippocampal CA1 neuronal programmed necrosis induced by global cerebral I/R injury is prevented by CA074-me (1 μg, 10 μg) both pre-treatment and post-treatment. The rupture of lysosomal membrane and the leakage of cathepsin-B, and this is strongly inhibited by CA074-me pre-treatment. The <br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專(zhuān)注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷(xiāo)網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀(guān)遺傳學(xué)等20個(gè)熱門(mén)研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過(guò)20種不同類(lèi)型的化合物庫(kù)，同時(shí)提供從毫克到千克的專(zhuān)業(yè)定制合成服務(wù)。</span>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/ca-074-methyl-ester.html">www.medchemexpress.cn/ca-074-methyl-ester.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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