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Calcipotriol (monohydrate)

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Calcipotriol-monohydrate.htmlCalcipotriol (monohydrate)/a產(chǎn)品描述：Calcipotriol mo
<a href="https://www.medchemexpress.com/Calcipotriol-monohydrate.html">Calcipotriol (monohydrate)</a>產(chǎn)品描述：Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the <b>vitamin D</b> receptor.

IC50 & Target: vitamin D receptor<sup>[1]</sup>

<i><b>In Vitro:</b></i> When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner<sup>[1]</sup>. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)<sub>2</sub>D<sub>3</sub>, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)<sub>2</sub>D<sub>3</sub>, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation<sup>[2<br><br>
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