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MRT68921 (hydrochloride)

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/MRT68921-hydrochloride.htmlMRT68921 (hydrochloride)/a產(chǎn)品描述：MRT68921 hydrochlor
<a href="https://www.medchemexpress.com/MRT68921-hydrochloride.html">MRT68921 (hydrochloride)</a>產(chǎn)品描述：MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM).

IC50 value: 2.9/1.1 nM (ULK1/2)

Target: ULK

in vitro: MRT68921 potently inhibits ULK1 and ULK2 and block autophagy in cells. MRT68921 specifically blocks autophagic flux through ULK1 inhibition. MRT68921 is able to inhibit the WT-restored ATG13 phosphorylation and autophagy similarly to cells expressing endogenous ULK1. [1]<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/mrt68921-hydrochloride.html">www.medchemexpress.cn/mrt68921-hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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