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SKF-96365 (hydrochloride)

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/SKF-96365-hydrochloride.htmlSKF-96365 (hydrochloride)/a產(chǎn)品描述：SKF-96365 hydroch
<a href="https://www.medchemexpress.com/SKF-96365-hydrochloride.html">SKF-96365 (hydrochloride)</a>產(chǎn)品描述：SKF-96365 hydrochloride, an <b>SOCE</b> inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.


<i><b>In Vitro:</b></i> SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner<sup>[1]</sup>. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects<sup>[2]</sup>.

<i><b>In Vivo:</b></i> SKF-96365 inhibits CRC cell growth <i>in vivo</i>. SKF-96365 treatment results in a de<br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/skf-96365-hydrochloride.html">www.medchemexpress.cn/skf-96365-hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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