138356-21-5：產品說明書

                                                <a href="https://www.medchemexpress.com/BD-1047-dihydrobromide.html">BD-1047 (dihydrobromide)</a>產品描述：BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. IC50 value: Target: sigma receptorin vitro: Moreover, Progesterone and BD 1047 (a sigma 1 receptor antagonist) counteracted the antidepressant-like effect induced by co-administration of Pramipexole and Sertraline (but not Pramipexole and Fluoxetine). [2] This increased pNR1 expression is significantly reduced by pretreatment with the specific Sig-1 R antagonist, BD-1047. In another set of experiments Sig-1 R agonists further potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity and this is also reversed with BD-1047. [3]in vivo: BD 1047 does not decrease amphetamine-induced hyperactivity in mice in a statistically significant manner. BD 1047 does not modify the hyperactivity induced by NMDA receptor antagonists. BD 1047 shows a moderate activity in models used in this study suggesting that its useful<br /><br /><br /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網點遍及全球20多個國家地區(qū)。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商， 產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">數千種產品在上海有充足備貨，24-48小時內送達客戶；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">大量產品提供免費試用裝；</span><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br /><br />產品鏈接：<a href="http://www.medchemexpress.cn/bd-1047-dihydrobromide.html">www.medchemexpress.cn/bd-1047-dihydrobromide.html</a><br /><br /><img alt=""  src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" style="width: 600.0px;height: 310.0px;" />                                            </div>