SKF-96365 (hydrochloride)產(chǎn)品描述:SKF-96365 hydrochloride, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a de 公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫,總部位于美國新澤西,分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理,營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域,PI3K、MAPK等近千個細分靶點,超過4000個活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫,同時提供從毫克到千克的專業(yè)定制合成服務。 MCE 對每批產(chǎn)品都進行嚴格的LCMS和NMR檢驗,其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利; MCE 定期增加各領域熱門抑制劑、激動劑,不斷擴增已有化合物庫,以滿足最新的科研需求; 數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時內送達客戶; 大量產(chǎn)品提供免費試用裝; 已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。 產(chǎn)品鏈接:www.medchemexpress.cn/skf-96365-hydrochloride.html src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" alt=""> |
SKF-96365 (hydrochloride)
發(fā)布日期:2017-10-25 瀏覽次數(shù):2
核心提示:a href=https://www.medchemexpress.com/SKF-96365-hydrochloride.htmlSKF-96365 (hydrochloride)/a產(chǎn)品描述:SKF-96365 hydroch
- 下一篇:暫無
- 上一篇:MRT68921 (hydrochloride)
行業(yè)動態(tài)
更多...
- SKF-96365 (hydrochloride 10-25
- MRT68921 (hydrochloride) 10-25
- 百億醫(yī)藥健康產(chǎn)業(yè)項目在余 12-07
- 第四屆中國—東盟藥品合作 12-06
- 加拿大阿爾伯塔省廢棄油井 07-28
- 中國醫(yī)藥產(chǎn)業(yè)政策細則落地 07-28
- 醫(yī)生“去編制化”讓深圳醫(yī) 07-28
- 甘肅省醫(yī)療機構新增項目價 07-28
- 甘肅省醫(yī)療機構新增項目價 07-28
- 備案制下,如何提高BE試驗 07-28